A novel fluorous chiral solvating agent

In the year 2015 Anikó Nemes et al. disclosed the synthesis and application of O-(nonafluoro-tert-butyl)mandelic acid [(R)-1] – containing nine equivalent fluorine atoms per molecule– for the chiral recognition of amines using 19F NMR spectroscopy in the Journal of Organic Chemistry.

The merits of using this fluorous chiral NMR shift reagent [(R)-1] were highlighted in the review paper by Márco S. Silva, entitled ’Recent advances in multinuclear NMR spectroscopy for chiral recognition of organic compounds’, published in the February 2017 issue of Molecules – an open access journal.